SLU-PP-332

Product Overview

SLU-PP-332 is a potent ERR agonist acting most strongly at ERRα (EC50 = 98 nM). Classified as an exercise mimetic, it reproduces metabolic and structural effects of physical activity at the cellular level by activating pathways normally triggered by endurance training. Unlike injectables or stimulants, it is taken orally, does not require cycling, and does not suppress endogenous hormone production.

Mechanism of Action

SLU-PP-332 binds to and activates ERRα with high affinity, triggering expression of hundreds of exercise-related genes including PGC-1α (master regulator of mitochondrial biogenesis), GLUT4 (glucose transporter), uncoupling proteins (thermogenesis), and fatty acid oxidation enzymes. This produces a broad shift in cellular energy metabolism from storage to utilization.

Key Benefits

Exercise Mimetic Effects — Activates genes normally triggered only by acute aerobic exercise, even in sedentary subjects. Boosts mitochondrial function, cellular respiration, and energy expenditure.

Weight Loss Without Lifestyle Changes — Obese mouse studies show up to 12% body weight loss without altering food intake or exercise habits. Shifts metabolism toward fat burning.

Improved Metabolic Health — Enhances fatty acid oxidation, combats metabolic syndrome, and improves insulin sensitivity. Reduces risk factors for heart disease and diabetes.

Enhanced Muscle Function — Boosts mitochondrial activity in skeletal muscle, producing stronger, more oxidative muscle fibers. Translates to improved endurance and performance.

References

1. Billon C, et al. Synthetic ERRα/β/γ agonist induces an ERRα-dependent acute aerobic exercise response. *ACS Chem Biol.* 2023;18(4):756–771.
2. Wang XX, et al. Estrogen-related receptor agonism reverses mitochondrial dysfunction and inflammation in the aging kidney. *Am J Pathol.* 2023;193(12):1969–1987.
3. Booth FW, et al. Lack of exercise is a major cause of chronic diseases. *Compr Physiol.* 2012;2:1143–1211.