Semax
Semax is a synthetic nootropic peptide analog of ACTH(4-10), developed in Russia. It delivers neurotrophic benefits without hormonal side effects by modulating dopamine/serotonin systems, increasing BDNF, and regulating the HPA axis. Clinically enhances memory, attention, and cognitive function while reducing anxiety and supporting stroke recovery. Available as nasal spray or lyophilized powder with ≥98% purity.
Available SKUs
| Model | Specification | MOQ |
|---|---|---|
| semax-5 | 5ml | 1 vial |
| semax-10 | 10ml | 1 vial |
| semax-20 | 20ml | 1 vial |
Product Overview
Semax mimics only a fragment of ACTH, delivering neurotrophic effects (neuron survival and growth support) without the endocrine effects of full-length ACTH (cortisol/androgen release). Developed in the 1980s by the Institute of Molecular Genetics of the Russian Academy of Sciences, it has been extensively studied for cognitive enhancement, neuroprotection, and mood regulation.
Mechanism of Action
Semax modulates dopaminergic and serotonergic systems for mood regulation and cognition. It increases Brain-Derived Neurotrophic Factor (BDNF) in the hippocampus and prefrontal cortex, supporting neuron survival, synaptogenesis, and neural plasticity. It regulates the HPA axis to normalize cortisol output after chronic stress. Additionally, it improves cerebral blood flow and provides antioxidant protection for neural cells.
Key Benefits
Cognitive Enhancement — Significant improvement in cognitive function demonstrated in clinical studies. Enhances brain Default Mode Network activity. Potential ADHD treatment without typical stimulant side effects.
Mood Regulation — Anti-depressant and anti-anxiety effects through serotonin and BDNF modulation. Improves mood in patients with motor neuron disease. Reduces anxiety without sedation.
Neurotrophic Support — Elevates BDNF in key brain regions, promoting neuron survival, synaptic plasticity, and stress resilience. Supports learning, memory, and neural circuit repair.
HPA Axis Normalization — Reduces post-chronic-stress cortisol overflow, restoring hormonal balance and indirectly supporting reproductive health by reducing cortisol's suppression of GnRH.
References
- Pae CU. Therapeutic possibility of Semax for depression. *CNS Spectr.* 2008;13(1):20–21.
- Liu W, et al. Brain-derived neurotrophic factor and its potential therapeutic role in stroke comorbidities. *Neural Plast.* 2020;2020:1969482.
- Westbrook A, Braver TS. Dopamine does double duty in motivating cognitive effort. *Neuron.* 2016;89(4):695–710.
| CAS Number | 80714-61-0 |
|---|---|
| Molecular Formula | C37H51N9O10S |
| Molecular Weight | 813.92 g/mol |
| Sequence/Composition | Met-Glu-His-Phe-Pro-Gly-Pro |
| Amino Acids | 7 |
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC |
| Storage | -20°C desiccated |
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