Pinealon
Pinealon (EDR peptide) is a synthetic tripeptide (Glu-Asp-Arg) derived from the neuropeptide complex Cortexin. It functions as a peptide bioregulator with neuroprotective, sleep-regulatory, and geroprotective properties. Its mechanism involves regulating gene expression, suppressing oxidative stress, stabilizing mitochondria, and supporting serotonin synthesis. Available as lyophilized powder with ≥98% purity.
Available SKUs
| Model | Specification | MOQ |
|---|---|---|
| pinealon-5 | 5ml | 1 vial |
| pinealon-10 | 10ml | 1 vial |
| pinealon-20 | 20ml | 1 vial |
Product Overview
Pinealon belongs to a class of ultra-short peptide bioregulators developed in Russia. Its simpler tripeptide structure provides higher stability, better tissue penetration, and lower immunogenic risk compared to its parent compound Cortexin. Pinealon interacts directly with the cell genome, regulating gene expression and modulating cellular processes including ROS accumulation, cell cycle progression, and neuronal repair.
Mechanism of Action
Pinealon regulates mRNA expression associated with neuronal repair, suppresses oxidative stress and free radical damage, stabilizes mitochondria under metabolic load, supports melatonin-associated circadian balance, and modulates apoptosis-related signaling pathways. It also promotes 5-tryptophan hydroxylase expression through epigenetic modifications, supporting serotonin synthesis.
Key Benefits
Neuroprotection — Reduces reactive oxygen species accumulation and necrotic cell death in brain tissue. Supports neuronal survival by suppressing oxidative stress and stabilizing mitochondrial function.
Sleep Regulation — Influences the sleep-wake cycle by supporting pineal gland function and circadian rhythm normalization. May mitigate disruptions from shift work and jet lag.
Cognitive Enhancement — Supports both short-term and long-term memory through neural pathway optimization. Enhances learning retention, particularly beneficial for learning-intensive tasks.
Cellular Anti-Aging — Modulates irisin expression in muscle cells (supporting telomere protection), decelerates cellular aging markers in the CNS, and promotes fat oxidation pathways.
References
- Meshchaninov VN, et al. Effect of synthetic peptides on aging of patients with chronic polymorbidity. *Advances in Gerontology.* 2015;28(1):62–67.
- Karantysh GV, et al. Effect of Pinealon on learning and expression of NMDA receptor subunit genes in rats with experimental diabetes. *Neurochem J.* 2020;14(3):314–320.
- Childs BG, et al. Senescent cells: an emerging target for diseases of ageing. *Nat Rev Drug Discov.* 2017;16:718–735.
| CAS Number | 1206780-50-2 |
|---|---|
| Molecular Formula | C13H24N6O8 |
| Molecular Weight | 392.36 g/mol |
| Sequence/Composition | Glu-Asp-Arg |
| Amino Acids | 3 |
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC |
| Storage | -20°C desiccated |
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