NAD+ (Nicotinamide Adenine Dinucleotide)
NAD+ is a vital coenzyme found in all living cells, central to energy metabolism, DNA repair, and cellular aging. It converts nutrients into ATP in mitochondria, activates longevity-linked sirtuins, and enables DNA repair enzymes like PARP. NAD+ levels decline by up to 50% between ages 30 and 70. Supplementation supports metabolism, cognitive function, and healthy aging. Available as lyophilized powder.
Available SKUs
| Model | Specification | MOQ |
|---|---|---|
| nad-5 | 5ml | 1 vial |
| nad-10 | 10ml | 1 vial |
| nad-20 | 20ml | 1 vial |
Product Overview
NAD+ (nicotinamide adenine dinucleotide) exists in oxidized (NAD+) and reduced (NADH) forms. The NAD+/NADH ratio is a critical measurement of cellular redox state and metabolic health, typically around 700:1 in the cytoplasm of healthy mammalian tissues. NAD+ is synthesized through de novo pathways from tryptophan or salvage pathways recycling nicotinamide. Age-related decline in NAD+ levels (approximately 50% between ages 30–70) drives reduced cellular function and increased susceptibility to age-related diseases.
Mechanism of Action
NAD+ serves as a key coenzyme in mitochondrial energy metabolism, converting nutrients into adenosine triphosphate (ATP). It activates sirtuins — a family of proteins involved in energy metabolism, DNA repair, and cellular aging. When cells experience oxidative stress or radiation damage, DNA repair enzymes like PARP consume large amounts of NAD+ to initiate repair and maintain genetic stability.
Key Benefits
Cellular Energy Production — Essential cofactor for converting nutrients to ATP in mitochondria. Boosting NAD+ enhances mitochondrial function and removes damaged mitochondria, improving overall metabolic efficiency.
Sirtuin Activation & Anti-Aging — Activates sirtuin proteins linked to longevity, energy metabolism, and DNA repair. Helps slow age-related cellular decline.
DNA Repair & Genomic Stability — Powers PARP enzymes for DNA damage repair, maintaining genetic integrity under oxidative stress and environmental damage.
Cognitive Enhancement — Suppresses neuroinflammation and improves cognitive performance, supporting long-term brain health.
References
- Nelson DL, Cox MM. *Principles of Biochemistry.* 4th ed. 2005.
- Abdellatif M, et al. NAD+ metabolism in cardiac health, aging, and disease. *Circulation.* 2021;144(22):1795–1817.
- Conlon NJ. The role of NAD+ in regenerative medicine. *Plast Reconstr Surg.* 2021;150:41S–48S.
| CAS Number | 53-84-9 |
|---|---|
| Molecular Formula | C21H27N7O14P2 |
| Molecular Weight | 663.43 g/mol |
| Sequence/Composition | N/A (dinucleotide coenzyme) |
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC |
| Storage | -20°C desiccated |
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