CJC-1295 Without DAC (Mod GRF 1-29)

Product Overview

CJC-1295 Without DAC, also known as Modified GRF 1-29, is a truncated synthetic form of GHRH with four amino acid substitutions designed to resist degradation and oxidation while enhancing GHRH receptor binding. Unlike the DAC version, this form has a shorter half-life, enabling more natural pulsatile growth hormone release patterns. It has been shown to increase serum growth hormone levels by 200–1000%.

Mechanism of Action

Upon administration, CJC-1295 Without DAC binds to growth hormone secretagogue receptors on pituitary somatotroph cells, stimulating growth hormone synthesis and release. Its short half-life enables rapid metabolism, producing natural GH pulse patterns. This works in concert with the body's feedback systems rather than bypassing them.

Key Benefits

Muscle Growth & Fat Loss — Promotes protein synthesis, stimulates muscle stem cell proliferation, and facilitates fatty acid mobilization and oxidation. Creates a favorable anabolic environment for muscle building and fat metabolism.

Growth Hormone Optimization — Offers a physiological approach to addressing GH deficiency by stimulating natural production rather than bypassing the body's regulatory mechanisms. Works in concert with the body's feedback systems.

Anti-Aging Potential — Targets the somatopause (age-related GH decline) associated with reduced exercise capacity, decreased bone density, and slowed wound healing. Users report enhanced cognitive function, improved memory, and sharper thinking.

Recovery Acceleration — Stimulates protein synthesis in skeletal muscle, promotes cell proliferation for muscle fiber repair, and supports collagen synthesis in connective tissues. Re-establishes perfusion to injured areas for faster healing.

References

1. Mendias CL, et al. The use of recombinant human growth hormone to protect against muscle weakness in ACL reconstruction patients. *Am J Sports Med.* 2020;48(8):1916–1928.
2. Baumgarten KM, et al. Can human growth hormone accelerate tendon and ligament injury recovery? *Sports Health.* 2025;17(2):299–304.
3. Memdouh S, et al. Advances in the detection of growth hormone releasing hormone synthetic analogs. *Drug Test Anal.* 2021;13(11–12):1871–1887.