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Cerebrolysin
Cerebrolysin is a peptide-based neuroprotective mixture derived from porcine brain tissue, containing neurotrophic factors including BDNF, NGF, GDNF, and CNTF. It promotes neurogenesis, neuroplasticity, and neuroprotection by modulating key signaling pathways. Used across Eurasian countries for stroke recovery, dementia, traumatic brain injury, and cognitive enhancement. Available as solution for injection.
Available SKUs
| Model | Specification | MOQ |
|---|---|---|
| cerebrolysin-5 | 5ml | 1 vial |
| cerebrolysin-10 | 10ml | 1 vial |
| cerebrolysin-20 | 20ml | 1 vial |
Product Overview
Cerebrolysin (developmental code FPF-1070) is an enzymatically-treated peptide preparation from pig brain containing brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor, nerve growth factor, and ciliary neurotrophic factor. It crosses the blood-brain barrier, and its biological effects mirror those of endogenous neurotrophic factors. It is used clinically in dozens of Eurasian countries for acute and chronic central nervous system disorders.
Mechanism of Action
Cerebrolysin induces neurogenesis, neuroplasticity, and neuroprotection by modulating two key signaling pathways: the Neurotrophic Factor (NTF) Pathway for maintaining and restoring neuronal networks, and the Sonic Hedgehog (Shh) Signaling Pathway for brain organization and structure.
Key Benefits
Neurological Disorder Support — Improves symptoms in autism spectrum disorder, ADHD, and cerebral palsy by modulating neurotransmitter systems and reducing neuroinflammation. Enhances attention span, impulse control, and behavioral regulation.
Cognitive Enhancement — Promotes release of neurotrophic factors (NGF, BDNF) supporting neuronal survival and synaptic plasticity. Modulates cholinergic, dopaminergic, and glutamatergic pathways for improved memory, focus, and information processing.
Cerebral Energy Metabolism — Enhances mitochondrial energy production, supporting the brain's high metabolic demands (approximately 20% of total body energy). Improves ATP availability for synaptic transmission and neurotransmitter synthesis.
Cerebral Blood Flow Improvement — Repairs damaged cerebral microvasculature through angiogenesis promotion, endothelial cell survival enhancement, and blood-brain barrier integrity restoration.
Neuroprotection — Reduces excitotoxicity by modulating glutamate receptors and calcium ion influx. Mitigates oxidative stress by enhancing endogenous antioxidant defenses. Particularly beneficial in acute conditions such as stroke or traumatic brain injury.
References
- Muresanu DF, et al. Cerebrolysin and Recovery After Stroke (CARS): A randomized, placebo-controlled, double-blind, multicenter trial. *Stroke.* 2016;47(1):151–159.
- Zhang D, et al. Efficacy and safety of Cerebrolysin for acute ischemic stroke: A meta-analysis. *BioMed Res Int.* 2017;2017:4191670.
- Fiani B, et al. Cerebrolysin for stroke, neurodegeneration, and traumatic brain injury: review of the literature. *Neurol Sci.* 2021;42(4):1345–1353.
| Molecular Formula | Mixture of neuropeptides |
|---|---|
| Molecular Weight | ~10,000 (mixture) g/mol |
| Sequence/Composition | Polypeptide mixture |
| Amino Acids | Mixture |
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC |
| Storage | -20°C desiccated |
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