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BPC-157
BPC-157 is a synthetic pentadecapeptide derived from a protective protein found in human gastric juice. It demonstrates remarkable regenerative effects across multiple tissue types including skin, muscle, bone, ligaments, and tendons. Known for exceptional stability in gastric juice (>24 hours), supporting oral administration. Available as lyophilized powder with ≥98% purity.
Available SKUs
| Model | Specification | MOQ |
|---|---|---|
| bpc157-5 | 5ml | 1 vial |
| bpc157-10 | 10ml | 1 vial |
| bpc157-20 | 20ml | 1 vial |
Product Overview
BPC-157 (Body Protection Compound 157) is a 15-amino acid peptide synthesized using solid-phase peptide synthesis. It is derived from human gastric juice and has been extensively researched for its regenerative and tissue-protective effects. Its remarkable stability in the gastric environment distinguishes it from most peptides, enabling both injectable and oral routes of administration.
Mechanism of Action
BPC-157 activates the VEGFR2 pathway to stimulate angiogenesis and promotes nitric oxide synthesis to improve blood vessel dilation and circulation. It up-regulates growth factors including EGR-1, activates FAK-paxillin complexes for cell migration and cytoskeletal reorganization, and stimulates the JAK-2 signaling pathway for cell survival and immune modulation.
Key Benefits
Angiogenesis & Tissue Repair — Activates the VEGFR2 pathway to promote new blood vessel formation. Enhances nitric oxide production, improving oxygen and nutrient delivery to damaged areas. Clinical evidence shows 7 of 12 patients with chronic knee pain experienced relief lasting over six months after a single BPC-157 injection.
Endothelial Function Support — Modulates caveolin-1 interaction with eNOS through the Src kinase pathway, enabling sustained nitric oxide production and maintained vasodilation for continuous blood flow to healing tissues.
Cellular Signaling & Repair — Activates FAK-paxillin complexes for wound cell migration, stimulates JAK-2 for cell survival, and triggers EGR-1 as a master transcriptional switch for organized healing.
Gut Health Support — As a gastric juice-derived peptide, BPC-157 promotes mucosal integrity throughout the gastrointestinal tract, enhances growth hormone receptor expression, modulates nitric oxide systems for mucosal blood flow, and reduces pro-inflammatory cytokines.
References
- Perovic D, et al. Novel therapeutic effects in rat spinal cord injuries by the administration of BPC 157 therapy. *Curr Issues Mol Biol.* 2022;44:1901–1927.
- Japjec M, et al. Stable gastric pentadecapeptide BPC 157 as a therapy for the disable myotendinous junctions in rats. *Biomedicines.* 2021;9:1547.
- Stuehr DJ, et al. A natural heme deficiency exists in biology that allows nitric oxide to control heme protein functions. *Bioessays.* 2023;45:e2300055.
| CAS Number | 137525-51-0 |
|---|---|
| Molecular Formula | C62H98N16O22 |
| Molecular Weight | 1419.53 g/mol |
| Sequence/Composition | GEPPPGKPADDAGLV |
| Amino Acids | 15 |
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC |
| Storage | -20°C desiccated |
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